1448231-41-1Relevant articles and documents
Synthesis of a new series of biphenyl-substituted, fused 1,2,4-triazoles by oxidative cyclisation and Dimroth rearrangement
Shurrab, Nabil Kh.,El-Louh, Ali K.,Al-Meghari, Iyad M.,Ferrwanah, Abed El Rahman
, p. 91 - 94 (2013/04/24)
A new series of 3-substituted-9-(1,1′-biphenyl-4-yl)-7-phenyl-7H- pyrazolo[4,3-e][1,2,4]triazolo [4,3-c]pyrimidines and 2-substituted-9-(1, 1′-biphenyl-4-yl)-7-phenyl-7H-pyrazolo[4,3-e][1,2,4] triazolo[1,5-c] pyrimidines were synthesised, as a new class of potent xanthine oxidase inhibitors, by oxidative cyclisation of 4-[2-(arylidene)hydrazinyl]-3-(1,1- biphenyl-4-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidines with FeCl3 in ethanol and Dimroth rearrangement. Keywords: hydrazones, nitrilimines, 1,5- electrocyclisation, heterocycles, Dimroth rearrangement.