1448295-71-3

Basic information

• Product Name: (S)-1-benzyl-2-(1-fluorovinyl)pyrrolidine
• Synonyms: (S)-1-benzyl-2-(1-fluorovinyl)pyrrolidine
• CAS NO: 1448295-71-3
• Molecular Weight: 205.275
• Mol File: 1448295-71-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-benzyl-2-(1-fluorovinyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-benzyl-2-(1-fluorovinyl)pyrrolidine(1448295-71-3)
• EPA Substance Registry System: (S)-1-benzyl-2-(1-fluorovinyl)pyrrolidine(1448295-71-3)

Safety Data

• Hazardous Substances Data: 1448295-71-3(Hazardous Substances Data)

Upstream product

• 138052-86-5 (S)-1-(1-benzylpyrrolidin-2-yl)ethanone 
• 1260610-09-0 (S)-1-benzyl-N-methoxy-N-methylpyrrolidine-2-carboxamide 
• 31795-93-4 N-benzyl-L-proline 

Relevant articles and documents

Preparation of fluoroalkenes via the Shapiro reaction: Direct access to fluorinated peptidomimetics

Fluoroalkenes represent a useful class of peptidomimetics with distinct biophysical properties. Current preparations of this functional group commonly provide mixtures of E- or Z-fluoroalkene diastereomers, and/or mixtures of nonfluorinated products. To directly access fluoroalkenes in good stereoselectivity, a Shapiro fluorination reaction was developed. Fluoroalkene products were accessed in one- or two-step sequences from widely available ketones. This strategy should be useful for the preparation of fluorinated analogs of peptide-based therapeutics, many of which would be challenging to prepare by alternate strategies.