138052-86-5

Basic information

• Product Name: Ethanone, 1-[1-(phenylmethyl)-2-pyrrolidinyl]-, (S)-
• CAS NO: 138052-86-5
• Molecular Formula: C13H17NO
• Molecular Weight: 203.284
• Mol File: 138052-86-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[1-(phenylmethyl)-2-pyrrolidinyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[1-(phenylmethyl)-2-pyrrolidinyl]-, (S)-(138052-86-5)
• EPA Substance Registry System: Ethanone, 1-[1-(phenylmethyl)-2-pyrrolidinyl]-, (S)-(138052-86-5)

Safety Data

• Hazardous Substances Data: 138052-86-5(Hazardous Substances Data)

Upstream product

• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 100-52-7 benzaldehyde 
• 74798-56-4 1-benzyl-2-methylpiperidin-3-one 
• 1260610-09-0 (S)-1-benzyl-N-methoxy-N-methylpyrrolidine-2-carboxamide 
• 75-16-1 methylmagnesium bromide 
• 31795-93-4 N-benzyl-L-proline 
• 147-85-3 L-proline 
• 83528-04-5 (S)-N-benzyl-O-benzylpyrrolidine-2-carboxylate 
• 917-54-4 methyllithium 
• 177559-01-2 3-(benzyloxy)-2-methylpyridine 
• 5291-77-0 1-benzyl-2-pyrrolidone 
• 1121-25-1 2-methyl-3-pyridinol 
• 72219-09-1 1-benzylpyrrolidine-2-carbonitrile 

Downstream Products

• 138052-95-6 2-((S)-1-Benzyl-pyrrolidin-2-yl)-3-methoxy-penta-3,4-dien-2-ol 
• 1448295-71-3 (S)-1-benzyl-2-(1-fluorovinyl)pyrrolidine 
• 138052-89-8 (R)-α-Methyl-α-acetyl-1-benzyl-2(S)-pyrrolidinemethanol 
• 138052-90-1 (S)-α-Methyl-α-acetyl-1-benzyl-2(S)-pyrrolidinemethanol 
• 91550-07-1 1-((1R,7aS)-1-Methyl-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-ethanone 
• 138052-87-6 (2S)-α-Methyl-α-1-(1-ethoxyethenyl)-1-benzylpyrrolidinemethanol 

Relevant articles and documents

Preparation of fluoroalkenes via the Shapiro reaction: Direct access to fluorinated peptidomimetics

Fluoroalkenes represent a useful class of peptidomimetics with distinct biophysical properties. Current preparations of this functional group commonly provide mixtures of E- or Z-fluoroalkene diastereomers, and/or mixtures of nonfluorinated products. To directly access fluoroalkenes in good stereoselectivity, a Shapiro fluorination reaction was developed. Fluoroalkene products were accessed in one- or two-step sequences from widely available ketones. This strategy should be useful for the preparation of fluorinated analogs of peptide-based therapeutics, many of which would be challenging to prepare by alternate strategies.

The First Enantioselectice Total Syntheses of the Allopumiliotoxin A Alkaloids 267A and 339B

Short, highly stereocontrolled, asymmetric total syntheses of the title amphibian alkaloids are described.In the first stage the indolizidine ketone 11 is assembled from L-proline in enantiomerically pure form.This short sequence proceeds in five laborato