1448321-33-2

Upstream product

• 373-44-4 1,8-diaminooctan 
• 501-53-1 benzyl chloroformate 
• 1002-57-9 8-Aminooctanoic acid 
• 160677-42-9 C₁₉H₃₈N₄O₄ 
• 23434-40-4 8-(benzyloxycarbonylamino)octanoic acid 
• 207857-15-6 1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine 

Downstream Products

• 1448321-36-5 benzyl (8-(4-((tert-butoxycarbonyl)imino)-2-oxo-1,3,5-triazacyclotridecan-1-yl)octyl)carbamate 
• 1000005-24-2 C₃₅H₆₁N₅O₆ 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS USEFUL AS CHITINASE INHIBITORS

The present invention relates to macrocyclic compounds of formula (I) and their use as chitinase inhibitors as well as to pharmaceutical compositions and methods of preparation thereof. The compounds can in particular be used in the treatment, prevention and/or amelioration of asthma.

Novel macrocyclic amidinoureas: Potent non-azole antifungals active against wild-type and resistant Candida species

Novel macrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agents against wild-type and fluconazole resistant Candida species. Macrocyclic compounds 11 and 18 were synthesized through a convergent approach using as a key step a ring-closing metathesis macrocyclization reaction, whereas compounds 25 were obtained by our previously reported synthetic pathway. All the macrocyclic amidinoureas showed antifungal activity toward different Candida species higher or comparable to fluconazole and resulted highly active against fluconazole resistant Candida strains showing in many cases minimum inhibitory concentration values lower than voriconazole.