1448321-36-5Relevant academic research and scientific papers
MACROCYCLIC COMPOUNDS USEFUL AS CHITINASE INHIBITORS
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Paragraph 0125; 0159-0161, (2021/07/29)
The present invention relates to macrocyclic compounds of formula (I) and their use as chitinase inhibitors as well as to pharmaceutical compositions and methods of preparation thereof. The compounds can in particular be used in the treatment, prevention and/or amelioration of asthma.
A gram-scale synthesis of a macrocyclic amidinourea with strong antifungal activity through a Fukuyama tri-protected polyamine intermediate
Borgini, Matteo,Orofino, Francesco,Truglio, Giuseppina I.,Balestri, Lorenzo,Botta, Maurizio
, p. 168 - 177 (2019/07/09)
Systemic fungal infections are, nowadays, of crucial importance and, thus, in the last decade, we explored the great potential of natural and synthetic guanylated compounds, a great amount of work that led to the development of new non-azole antifungal co
Novel macrocyclic amidinoureas: Potent non-azole antifungals active against wild-type and resistant Candida species
Sanguinetti, Maurizio,Sanfilippo, Stefania,Castagnolo, Daniele,Sanglard, Dominique,Posteraro, Brunella,Donzellini, Giovanni,Botta, Maurizio
, p. 852 - 857 (2013/10/01)
Novel macrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agents against wild-type and fluconazole resistant Candida species. Macrocyclic compounds 11 and 18 were synthesized through a convergent approach using as a key step a ring-closing metathesis macrocyclization reaction, whereas compounds 25 were obtained by our previously reported synthetic pathway. All the macrocyclic amidinoureas showed antifungal activity toward different Candida species higher or comparable to fluconazole and resulted highly active against fluconazole resistant Candida strains showing in many cases minimum inhibitory concentration values lower than voriconazole.
