1448419-06-4Relevant academic research and scientific papers
Phosphodiesterase inhibitors and uses thereof
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, (2020/05/12)
The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibitio
Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease
Fiorito, Jole,Vendome, Jeremie,Saeed, Faisal,Staniszewski, Agnieszka,Zhang, Hong,Yan, Shijun,Deng, Shi-Xian,Arancio, Ottavio,Landry, Donald W.
, p. 8858 - 8875 (2017/11/14)
Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a transcriptional factor involved with learning and memory processes. We previously reported poten
NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
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, (2015/02/02)
The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibitio
NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
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, (2013/07/31)
The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibitio
