1448425-72-6Relevant articles and documents
Direct synthesis of diverse β-fluoroethylamines by a multicomponent protocol
Prakash, G. K. Surya,Gurung, Laxman,Jog, Parag V.,Tanaka, Shinji,Thomas, Tisa Elizabeth,Ganesh, Nimisha,Haiges, Ralf,Mathew, Thomas,Olah, George A.
, p. 3579 - 3583 (2013)
No imines! A direct multicomponent protocol for the synthesis of highly diverse derivatives of β-fluoro(phenylsulfonyl)ethylamine has been developed (see scheme) by use of a Mannich-type reaction from their molecular subunits, α-fluoro-α-nitro(phenylsulfonyl)methane (1 a) or α-fluorobis(phenylsulfonyl)methane (1 b), formalin, and various primary and secondary amines. The products are obtained in high yields and selectivity even, in many cases, without the use of base. Copyright
