1448449-94-2Relevant academic research and scientific papers
A concise synthesis of tunable fluorescent 1,3-dihydroisobenzofuran derivatives as new fluorophores
Shang, Xue Song,Li, Deng Yuan,Li, Nian Tai,Liu, Pei Nian
, p. 8 - 17 (2015/03/31)
A convenient potassium tert-butoxide catalyzed addition-elimination reaction has been achieved using exo-cyclic enol ethers and aryl aldehydes as the starting materials. The transition-metal free reaction proceeded smoothly to afford 1,3-dihydroisobenzofuran derivatives with good to excellent yields. More importantly, the resulting products were discovered as novel fluorophores with good fluorescence properties and remarkable Stokes shifts. Changing the nature of the substituents in 1,3-dihydroisobenzofurans derivatives allowed the maximum emission wavelengths to be tuned between 438 and 597 nm and the Stokes shifts varied between 63 and 166 nm. In particular, derivative C27 containing a piperidyl and a cyano group showed the maximum emission wavelength of 597 nm and a Stokes shift of 166 nm.
Transition metal-free cascade reactions of alkynols to afford isoquinolin-1(2H)-one and dihydroisobenzofuran derivatives
Li, Deng Yuan,Shi, Ke Ji,Mao, Xiao Feng,Chen, Guo Rong,Liu, Pei Nian
, p. 4602 - 4614 (2014/06/09)
Transition metal-free cascade reactions of alkynols with imines have been achieved using potassium tert-butoxide as catalyst. Switching the reaction solvent gives two kinds of products in good yield: isoquinolin-1(2H)-one derivatives and dihydroisobenzofuran derivatives. This approach was used to generate the natural product 8-oxypseudopalmatine in a two-step procedure from commercially available starting materials. Additionally, multicomponent reactions of alkynols, aldehydes, and amines were also successfully achieved to afford isoquinolin-1(2H)-one derivatives.
Solvent-switched benzylic methylene functionalization: Addition, ring-opening, cyclization, and unexpected cleavage of C-O and C-C bonds
Li, Deng Yuan,Shang, Xue Song,Chen, Guo Rong,Liu, Pei Nian
supporting information, p. 3848 - 3851 (2013/09/02)
Intermolecular benzylic methylene functionalization of exo-cyclic enol ethers has been achieved using imines as reagents and potassium tert-butoxide as the catalyst. Depending on the solvent used, the reaction proceeds by two pathways. In THF, an addition
