29539-19-3

Basic information

• Product Name: Isobenzofuran, 1,3-dihydro-1-(phenylmethylene)-
• CAS NO: 29539-19-3
• Molecular Formula: C15H12O
• Molecular Weight: 208.26
• Mol File: 29539-19-3.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Isobenzofuran, 1,3-dihydro-1-(phenylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isobenzofuran, 1,3-dihydro-1-(phenylmethylene)-(29539-19-3)
• EPA Substance Registry System: Isobenzofuran, 1,3-dihydro-1-(phenylmethylene)-(29539-19-3)

Safety Data

• Hazardous Substances Data: 29539-19-3(Hazardous Substances Data)

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 618-31-5 benzylidene dibromide 
• 13141-40-7 [2-(2-phenylethynyl)phenyl]methanol 
• 138695-53-1 (E)-1-benzylidene-1,3-dihydroisobenzofuran 
• 18982-54-2 o-bromobenzyl alcohol 
• 536-74-3 phenylacetylene 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 5159-41-1 2-iodobenzyl alcohol 
• 64-17-5 ethanol 
• 7695-69-4 bis(phenylthio)methylbenzene 

Downstream Products

• 87-41-2 2-benzofuran-1(3H)-one 
• 1448449-96-4 4-(4-((Z)-((Z)-3-benzylideneisobenzofuran-1(3H)-ylidene)methyl)phenyl)morpholine 
• 1448449-94-2 1-(4-((Z)-((Z)-3-benzylideneisobenzofuran-1(3H)-ylidene)methyl)phenyl)piperidine 
• 1448449-92-0 1-(4-((Z)-((Z)-3-benzylideneisobenzofuran-1(3H)-ylidene)methyl)phenyl)pyrrolidine 
• 1448450-00-7 4-((Z)-((Z)-3-benzylideneisobenzofuran-1(3H)-ylidene)methyl)-N,N-dimethylaniline 
• 1448449-88-4 (1Z,3Z)-1-benzylidene-3-(4-methoxybenzylidene)-1,3-dihydroisobenzofuran 
• 1448450-19-8 2-phenyl-3-(4-(pyrrolidin-1-yl)phenyl)isoquinolin-1(2H)-one 
• 1448449-90-8 4-((Z)-((Z)-3-benzylideneisobenzofuran-1(3H)-ylidene)methyl)-N,N-diethylaniline 
• 1448450-41-6 (1Z,3Z)-1-benzylidene-3-(1-(4-methoxyphenyl)ethylidene)-1,3-dihydroisobenzofuran 
• 1367766-62-8 2-cyclohexyl-3-phenylisoquinolin-1(2H)-one 
• 34497-12-6 3-phenyl-2-propylisoquinolin-1(2H)-one 
• 34497-10-4 2-methyl-3-phenylisoquinolin-1(2H)-one 
• 1448450-28-9 2-(3,5-dimethylphenyl)-3-phenylisoquinolin-1(2H)-one 
• 14959-65-0 2-(4-methoxyphenyl)-3-phenylisoquinolin-1(2H)-one 

Relevant articles and documents

Regio- and stereoselective intramolecular hydroalkoxylation of aromatic alkynols: an access to dihydroisobenzofurans under transition-metal-free conditions

An efficient, transition-metal-free method to synthesize dihydroisobenzofuran derivatives via intramolecular hydroalkoxylation of aromatic alkynols with the promotion of cesium carbonate has been developed. The reaction proceeds regioselectively with exclusive formation of 5-exo-dig product, and only Z-isomer of the new generated double bond is observed. This new protocol features with milder reaction conditions, more convenient operation and satisfactory selectivities.

Selective cyclization of alkynols and alkynylamines catalyzed by potassium tert-butoxide

Potassium tert-butoxide (t-BuOK) was found to be an effective catalyst for the cyclization of aromatic alkynols and alkynylamines. In the presence of 10 mol % t-BuOK, a range of alkynols were converted to the corresponding exo-cyclic enol ethers as pure Z

Regioselective synthesis and evaluation of 3-alkylidene-1, 3-dihydroisobenzofurans as potential antidepressant agents

3-Alkylidene-1,3-dihydroisobenzofurans exhibited moderate antidepressant activity as evaluated by forced swim and tail suspension test methods. Virtual screening was carried out by docking the designed compounds into the serotonin binding sites of arabinase protein to predict the analogue binding mode of the compounds to the SSRIs. [Figure not available: see fulltext.]