1448532-00-0

Basic information

• Product Name: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-ynyl)phenyl)acetamide
• Synonyms: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-ynyl)phenyl)acetamide
• CAS NO: 1448532-00-0
• Molecular Weight: 299.757
• Mol File: 1448532-00-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-ynyl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-ynyl)phenyl)acetamide(1448532-00-0)
• EPA Substance Registry System: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-ynyl)phenyl)acetamide(1448532-00-0)

Safety Data

• Hazardous Substances Data: 1448532-00-0(Hazardous Substances Data)

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 13788-59-5 N-(2-benzoyl-4-chlorophenyl)acetamide 
• 4301-14-8 acetylenemagnesium bromide 

Downstream Products

• 6765-75-9 5-chloro-3-phenyl-1H-indole-2-carbaldehyde 
• 1642628-10-1 (E)-N-(6-chloro-4-phenylquinolin-2(1H)-ylidene)-4-methylbenzenesulfonamide 

Relevant articles and documents

Tandem Cu-catalyzed ketenimine formation and intramolecular nucleophile capture: Synthesis of 1,2-dihydro-2-iminoquinolines from 1-(o-acetamidophenyl) propargyl alcohols

The copper-catalyzed ketenimine formation reaction of 1-(o-acetamidophenyl) propargyl alcohols with various sulfonyl azides is found to undergo a concomitant intramolecular nucleophile attack to generate 1,2-dihydro-2- iminoquinolines after aromatization (via elimination of acetyl and hydroxy groups) and tautomerization. The reaction produces 4-substituted and 3,4-unsubstituted title compounds in moderate to good yields under mild reaction conditions.