1448550-68-2Relevant academic research and scientific papers
Asymmetric synthesis and molecular docking study of enantiomerically pure pyrrolidine derivatives with potential antithrombin activity
Ayan, Seylan,Dogan, Oezdemir,Ivantcova, Polina M.,Datsuk, Nikita G.,Shulga, Dmitry A.,Chupakhin, Vladimir I.,Zabolotnev, Dmitry V.,Kudryavtsev, Konstantin V.
, p. 838 - 843 (2013)
The (2R,4R,5S)- and (2S,4S,5R)-enantiomers of 4-(tert-butyl) 2-methyl 5-(4-bromophenyl)-pyrrolidine-2,4-dicarboxylate 3 were synthesized efficiently with an ee of >90% on a gram scale using a FAM-catalytic methodology. Subsequent modification afforded ena
