1448586-48-8

Basic information

• Product Name: C₃₇H₄₅ClN₆O₄S
• CAS NO: 1448586-48-8
• Molecular Weight: 705.321
• Mol File: 1448586-48-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₇H₄₅ClN₆O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₄₅ClN₆O₄S(1448586-48-8)
• EPA Substance Registry System: C₃₇H₄₅ClN₆O₄S(1448586-48-8)

Safety Data

• Hazardous Substances Data: 1448586-48-8(Hazardous Substances Data)

Upstream product

• 64-04-0 phenethylamine 
• 187618-60-6 Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine 
• 90723-71-0 6-chloro-4-methyl-2-chloroquinoline 
• 1448586-47-7 (S)-2-amino-N-(pbf)-5-guanidino-N-phenethylpentanamide 

Relevant articles and documents

N -heteroarylation of chiral α-aminoesters by means of palladium-catalyzed buchwald-hartwig reaction

N-Heteroaryl-α-amino acid derivatives are valuable pharmacological agents as peptidomimetics. Classical SNAr methods using acid catalysis and elevated temperatures could not be extended to various α-amino acids and fairly electrophilic heterocyclic partners. Here, we report a mild and versatile method of N-heteroarylation of chiral α-aminoesters without racemization, involving Buchwald-Hartwig conditions. It could be extended to various α-amino acids and azines. This efficient N-heteroarylation leads to (i) a chemical library of putative peptidomimetics combining diverse azaheterocycles with the chiral α-aminoesters and their corresponding derivatives (amides, alcohols, etc.) and (ii) arginine derivatives designed as NPFF receptor ligands.