90723-71-0

Basic information

• Product Name: 2,6-DICHLORO-4-METHYLQUINOLINE
• Synonyms: 2,6-DICHLORO-4-METHYLQUINOLINE;2,6-dichloro-4-methylquinoline(SALTDATA: FREE)
• CAS NO: 90723-71-0
• Molecular Formula: C₁₀H₇Cl₂N
• Molecular Weight: 212.08
• Mol File: 90723-71-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 316 °C at 760 mmHg
• Flash Point: 174.2 °C
• Appearance: /
• Density: 1.351 g/cm³
• Vapor Pressure: 0.00078mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 2,6-DICHLORO-4-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLORO-4-METHYLQUINOLINE(90723-71-0)
• EPA Substance Registry System: 2,6-DICHLORO-4-METHYLQUINOLINE(90723-71-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 90723-71-0(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-4-methylquinoline is a chemical compound with the molecular formula C10H6Cl2N. It is a substituted quinoline, which is a class of heterocyclic aromatic compounds. This chemical is used in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of dyes, pigments, and other organic compounds. 2,6-Dichloro-4-methylquinoline is known to have potential biological activities, including antimicrobial and antitumor properties. It is important for researchers and chemists in the development of new drugs and chemicals with various applications.

InChI:InChI=1/C10H7Cl2N/c1-6-4-10(12)13-9-3-2-7(11)5-8(6)9/h2-5H,1H3

Upstream product

• 2585-04-8 6-chloro-4-methyl-quinolin-2-ol 
• 101-92-8 4'-Chloroacetoacetanilide 
• 20139-55-3 N-(2-methyl-4-chlorophenyl)-3-oxobutanamide 
• 104678-53-7 2,6-dichloro-4-methyl-4-nitrocyclohexa-2,5-dienone 
• 64-19-7 acetic acid 

Downstream Products

• 61305-55-3 4-acetoxy-2,6-dichloro-4-methyl-cyclohexa-2,5-dienone 
• 860297-19-4 benzyl {(1S,3S)-3-[benzyloxycarbonyl-(6-chloro-4-methylquinolin-2-yl)amino]cyclohexyl}carbamate 
• 1315380-22-3 6-chloro-4-methyl-2-(4'-methyl-phenylamino)quinoline 
• 1315380-28-9 2-(9-chloro-2-methyl-12-phenyldibenzo[b,g][1,8]naphthyridin-11(6H)-ylidene)-1-phenylethanone 
• 10562-10-4 6-chloro-4-methyl-2-(4'-chloro-phenylamino)quinoline 
• 1315380-18-7 2-(2,9-dichloro-12-phenyldibenzo[b,g][1,8]naphthyridin-11(6H)-ylidene)-1-phenylethanone 
• 1315380-02-9 2[(2'-benzoyl-4'-chlorophenyl)amino]-6-chloro-4-methylquinoline 
• 1448586-48-8 C₃₇H₄₅ClN₆O₄S 
• 108936-72-7 6-Chloro-2-(3,5-dimethyl-pyrazol-1-yl)-4-methyl-quinoline 
• 21703-54-8 2-hydrazino-6-chloro-4-methylquinoline 

Relevant articles and documents

Free energy perturbation guided Synthesis with Biological Evaluation of Substituted Quinoline derivatives as small molecule L858R/T790M/C797S mutant EGFR inhibitors targeting resistance in Non-Small Cell Lung Cancer (NSCLC)

Two different schemes of novel substituted quinoline derivatives were designed and synthesized via simple reaction steps and conditions. A comparative molecular docking study was carried out on two different types of EGFR enzymes which include wild-type (PDB: 4I23) and T790M mutated (PDB: 2JIV) respectively. Compounds were also validated upon T790M/C797S mutated (PDB ID: 5D41) EGFR enzyme at the allosteric binding site. Free energy perturbations were carried out to determine the absolute binding free energy of a protein–ligand complex in the form of ΔGbinding, which in turn provided 4ab and 5ad as the most potential contenders through the structural enhancement in the determined initial scaffolds. Anticancer activity of the synthesized derivatives was examined against HCC827, H1975 (L858R/T790M), A549, and HT-29 cell lines by standard MTT assay. Compound 4ad (6-chloro-2-(isoindolin-2-yl)-4-methylquinoline) has shown excellent inhibitory activities against mutant EGFR kinase with IC50 value 0.91 μM. The potency of compounds 4ab, 4ad and 5ad was compared through an insilico ADMET study.

Compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds

The invention provides 7-substituted-5-methyl-1,2,4-triazolo[4,3-a] quinoline and 7-substituted-5-ethoxy-[1,2,4]-triazolo[4,3-a] quinoline compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds in the field of preparing anticonvulsion medicines.