1448592-67-3

Upstream product

• 1448592-55-9 (3-bromo-4,5-dichloro-1H-pyrrol-2-yl)(2,3,4-trimethoxyphenyl)methanone 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 368211-06-7 1H-pyrrole-2-carboxylic acid methoxymethylamide 
• 1448592-72-0 4, 5-dichloro-N-methoxy-N-methyl-1H-pyrrole-2-carboxamide 
• 1448592-66-2 3-bromo-4,5-dichloro-1H-pyrrole-2-carboxylic acid methoxymethyl amide 

Relevant academic research and scientific papers

MCL-1 MODULATING COMPOSITIONS

The present invention relates to marinopyrrole A derivatives and pyoluteorin derivatives and methods of treatment of disorders associated with misregulation of Mcl-l, e.g., leukemia, lymphoma, multiple myeloma, melanoma, or pancreatic cancer. We describe exemplary compounds, which may be contained in pharmaceutical compositions, and their use as therapeutic agents either alone or in combination with other anti-cancer treatments, e.g., anti-Bcl- 2 agents.