144868-47-3

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 111-29-5 1 ,5-pentanediol 
• 131375-63-8 5-(4-methoxybenzyloxy)-1-pentanol 

Downstream Products

• 859844-95-4 (R)-7-(4-Methoxy-benzyloxy)-2-methyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 
• 1334774-64-9 (2R,3R,4R,5S)-4,5-dibenzyloxy-1-benzyloxycarbonyl-2-benzyloxymethyl-3-[5-(p-methoxybenzyloxy)pentyloxy]piperidine 
• 1334774-69-4 (2R,3R,4R,5S)-4,5-dibenzyloxy-1-benzyloxycarbonyl-2-benzyloxymethyl-3-(5-hydroxypentyloxy)piperidine 
• 676236-01-4 (4R)-4-{(2Z)-7-[(4-methoxybenzyl)oxy]hept-2-en-1-yl}cyclopent-2-en-1-one 
• 859844-98-7 (2S,6R)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(E)-(R)-8-(4-methoxy-benzyloxy)-1,3-dimethyl-oct-1-enyl]-4-triethylsilanyloxy-3,6-dihydro-2H-pyran 
• 859844-70-5 1-((E)-(R)-8-Bromo-6-methyl-non-7-enyloxymethyl)-4-methoxy-benzene 
• 859845-24-2 1-((R)-8,8-Dibromo-6-methyl-oct-7-enyloxymethyl)-4-methoxy-benzene 
• 859845-25-3 1-Methoxy-4-((R)-6-methyl-non-7-ynyloxymethyl)-benzene 
• 945265-71-4 (R)-7-(4-Methoxy-benzyloxy)-2-methyl-heptan-1-ol 
• 859845-23-1 (R)-7-(4-Methoxy-benzyloxy)-2-methyl-heptanal 

Relevant academic research and scientific papers

SYNTHESIS OF DELTA 12-PGJ3 AND RELATED COMPOUNDS

In one aspect, the present invention provides novel derivatives of Δ12-PGJ3 and modular synthetic pathways to obtaining Δ12-PGJ3 and derivatives thereof. In some aspects, the present derivatives of Δ12-PGJ3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

(+)-Sorangicin A synthetic studies. Construction of the C(1-15) and C(16-29) subtargets

(Chemical Equation Presented) Effective stereocontrolled syntheses of subtargets (-)-2 and (-)-4, comprising respectively the C(16-29) and C(1-15) tetrahydropyran and dihydropyran moieties of the potent antibiotic (+)-sorangicin A (1), have been achieved. The cornerstone for the synthesis of (-)-2 involved an aldol tactic exploiting 1,4-induction, followed in turn by an acid-mediated cyclization/ketalization and hydrosilane reduction promoted by TMSOTf, while construction of (-)-4 entailed a stereoselective conjugate addition/α-oxygenation sequence.