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Upstream product

• 111-29-5 1 ,5-pentanediol 
• 824-94-2 p-methoxybenzyl chloride 
• 144868-47-3 1-{[(5-iodopentyl)oxy]methyl}-4-methoxybenzene 
• 131375-63-8 5-(4-methoxybenzyloxy)-1-pentanol 
• 859844-95-4 (R)-7-(4-Methoxy-benzyloxy)-2-methyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 
• 859845-23-1 (R)-7-(4-Methoxy-benzyloxy)-2-methyl-heptanal 

Relevant academic research and scientific papers

Total synthesis of amphidinolide E and amphidinolide E stereoisomers

Four amphidinolide E stereoisomers, amphidinolide E (1), 2-epi-amphidinolide E (2), 19-epi-amphidinolide E (3), and 2-epi-19-epi-amphidinolide E (4), have been synthesized via the judicious union of aldehyde 5, allylsilanes 7 or 8, acids 9 or 10, and viny

(+)-Sorangicin A synthetic studies. Construction of the C(1-15) and C(16-29) subtargets

(Chemical Equation Presented) Effective stereocontrolled syntheses of subtargets (-)-2 and (-)-4, comprising respectively the C(16-29) and C(1-15) tetrahydropyran and dihydropyran moieties of the potent antibiotic (+)-sorangicin A (1), have been achieved. The cornerstone for the synthesis of (-)-2 involved an aldol tactic exploiting 1,4-induction, followed in turn by an acid-mediated cyclization/ketalization and hydrosilane reduction promoted by TMSOTf, while construction of (-)-4 entailed a stereoselective conjugate addition/α-oxygenation sequence.