1448695-65-5Relevant articles and documents
Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides
Kle?ka, Martin,Slavětínská, Lenka Po?tová,Tlou??ová, Eva,D?ubák, Petr,Hajdúch, Marián,Hocek, Michal
, p. 576 - 580 (2015)
A series of 7-phenylsulfanyl- or 7-(2-thienyl)sulfanyl-7-deazapurine bases bearing diverse substituents at position 6 was prepared through C-H sulfenylation of 6-chloro-7-deazapurine followed by cross-coupling or nucleophilic substitutions. The corresponding ribonucleosides (as thia-analogues of known nucleoside cytostatics) were prepared by glycosylation of 6-chloro-7-arylsulfanyl-7-deazapurines followed by the same transformations at position 6. The 7-thienylsulfanyl-7-deazapurine bases 2b-2h exerted micromolar cytostatic activities, whereas the nucleosides did not show significant biological effects. This journal is
Direct C-H sulfenylation of purines and deazapurines
Kle?ka, Martin,Pohl, Radek,?ejka, Jan,Hocek, Michal
, p. 5189 - 5193 (2013/08/23)
A general method for Cu-catalyzed C-H sulfenylation of purines, 7-deaza- and 9-deazapurines with aryl- or alkyldisulfides has been developed. In purines, the reaction occurs at position 8, in 7-deazapurines at position 7 and in 9-deazapurines at position 9, leading to new interesting arylsulfanyl derivatives of purine or deazapurine bases. The resulting 8-arylsulfanylpurines undergo Liebesking-Srogl coupling with arylstannanes or boronic acids, whereas the (arylsulfanyl)deazapurines are not reactive under these conditions.