144872-34-4

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-nitrophenyl)-3-piperidinone is used as an intermediate in the pharmaceutical industry for the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows for the creation of a wide range of medicinal products.
Used in Medical Research and Drug Development:
In the field of medical research, 1-(4-nitrophenyl)-3-piperidinone is utilized as a promising compound for drug development. Its potential pharmacological properties make it a valuable asset in the search for novel treatments and therapies.

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 6859-99-0 3-hydroxypiperazine 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 765962-69-4 3,3-dimethoxypiperidine 

Downstream Products

• 1418754-31-0 (1R,2R)-N₁-((S)-1-(4-nitrophenyl)piperidin-3-yl)cyclohexane-1,2-diamine 
• 1420459-78-4 C₂₇H₃₀F₃N₅O₄ 
• 1420459-80-8 C₂₄H₂₉N₅O₃ 
• 144872-25-3 3-(N-benzyl-N-methylamino)-1-(4-nitrophenyl)piperidine 

Relevant academic research and scientific papers

Origin of the E/Z Selectivity in the Synthesis of Tetrasubstituted Olefins by Wittig Reaction of α-Fluorophosphonium Ylides: An Explanation for the Low Stereoselectivity Observed in Reactions of α-Alkoxy Aldehydes

A series of tetrasubstituted fluoroalkenes were synthesized in good yield and high E/Z selectivity (up to 96/4) by Wittig reaction between α-heterosubstituted ketones and α-fluorophosphonium ylides. A detailed study of factors that control stereoselectivity in these reactions shows that stereoselectivity is the result of stabilizing CH···F and N···C=O interactions in the addition TS leading to the E isomer. This analysis provides a rationale for the observed decrease in selectivity for reactions of stabilized ylides with α-alkoxy aldehydes.

DIAMINOCYCLOHEXANE COMPOUNDS AND USES THEREOF

The present invention provides compounds of Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are agonists, partial agonists and modulators of the NPY Y4 rece