144872-70-8Relevant academic research and scientific papers
Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation
Cao, Yafei,Li, Qin,Liu, Da-Ke,Liu, Jianhui,Mao, Run-Ze,Xia, Feng,Xiong, De-Cai,Ye, Xin-Shan,Zhou, Minmin,Zou, You
, p. 10899 - 10902 (2021/10/25)
A new glycosylation method promoted by visible light with 3,5-dimethoxyphenyl glycoside as the donor was developed. This protocol delivers bothO-glycosides andN-glycosides in moderate to excellent yields using a wide range ofO-nucleophiles and nucleobases as the glycosyl acceptors.
A general method for N-glycosylation of nucleobases promoted by (p-Tol)2SO/Tf2O with thioglycoside as donor
Liu, Guang-Jian,Zhang, Xiao-Tai,Xing, Guo-Wen
supporting information, p. 12803 - 12806 (2015/08/06)
Based on a preactivation strategy using the (p-Tol)2SO/Tf2O system, a series of nucleosides were synthesized by coupling various thioglycosides with pyrimidines and purines under mild conditions. High yields and excellent β-stereoselectivities were obtained with either armed or disarmed N-glycosylation donors by tuning the amount of (p-Tol)2SO additive.
Effective synthesis of nucleosides with glycosyl trifluoroacetimidates as donors
Liao, Jinxi,Sun, Jiansong,Yu, Biao
, p. 5036 - 5038 (2008/12/21)
Glycosyl trifluoroacetimidates have been disclosed to be effective glycosyl donors for the synthesis of nucleosides; the present N-glycosylation protocol requires only a catalytic amount of TMSOTf as promoter and proceeds smoothly at room temperature.
