1448756-45-3Relevant academic research and scientific papers
Phosphine-free thiopseudourea-Pd(II) complex catalyzed Larock heteroannulation of 2-haloamines with internal alkynes
Srinivas, Keesara,Saiprathima, Parvathaneni,Balaswamy, Kodicherla,Ra, Mandapati Mohan
, p. 162 - 167 (2013)
We examined the Pd-catalyzed heteroannulation of 2-haloamines with internal alkynes under phosphinefree conditions. The thiopseudourea palladium(II) complex (5) found to be an efficient catalyst for the Pd induced heteroannulation. Achieved high turnover number for the heteroannulation reactions of internal alkynes with 2-iodoaniline. A variety of 2-bromoanilines and N-tosyl substituted 2-bromoanilines effectively reacted with different substituted internal alkynes to give the corresponding indoles in good to high yields (1:1 ratio of regioisomers).
