625091-78-3

Basic information

• Product Name: N-(2-bromo-4-fluorophenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(2-bromo-4-fluorophenyl)-4-methylbenzenesulfonamide
• CAS NO: 625091-78-3
• Molecular Weight: 344.204
• Mol File: 625091-78-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(2-bromo-4-fluorophenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-bromo-4-fluorophenyl)-4-methylbenzenesulfonamide(625091-78-3)
• EPA Substance Registry System: N-(2-bromo-4-fluorophenyl)-4-methylbenzenesulfonamide(625091-78-3)

Safety Data

• Hazardous Substances Data: 625091-78-3(Hazardous Substances Data)

Upstream product

• 103273-01-4 2-bromo-4-tert-butylaniline 
• 769-92-6 4-tert-Butylaniline 
• 1003-98-1 2-bromo-4-fluoroaniline 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1448756-45-3 5-fluoro-2,3-diphenyl-1-tosylindole 
• 10219-00-8 N-(4-fluorophenyl)-N,4-dimethylbenzenesulfonamide 

Relevant articles and documents

Directing-group-assisted markovnikov-selective hydrothiolation of styrenes with thiols by photoredox/cobalt catalysis

In contrast with the well-developed radical thiol-ene reaction to access anti-Markovnikov-type products, the research on the catalytic Markovnikov-selective hydrothiolation of alkenes is very restricted. Because of the catalyst poisoning of metal catalysts by organosulfur compounds, limited examples of transition-metal-catalyzed thiol-ene reactions have been reported. However, in this work, a directing-group-assisted hydrothiolation of styrenes with thiols by photoredox/cobalt catalysis is found to proceed smoothly to afford Markovnikov-type sulfides with excellent regioselectivity.

Visible-Light-Driven Neutral Nitrogen Radical Mediated Intermolecular Styrene Difunctionalization

A neutral nitrogen radical-mediation strategy, wherein the existing N-H moiety of substrates serves as a neutral nitrogen radical precursor to enable room-temperature intermolecular radical difunctionalization of styrenes under photoredox catalysis, is reported. The reaction shows high functional group tolerance and substrate scope with respect to both components, giving the corresponding products with generally good yields. Preliminary control experiments and DFT calculations are performed to explain the reaction mechanism.

Platform for Ring-Fluorinated Benzoheterole Derivatives: Palladium-Catalyzed Regioselective 1,1-Difluoroallylation and Heck Cyclization

The synthesis of difluoromethylene-containing heterocycles was achieved via the palladium-catalyzed 1,1-difluoroallylation of heteronucleophiles followed by intramolecular Heck reaction. The allylic substitution of 3-bromo-3,3-difluoropropene was regiosel