1448778-58-2Relevant academic research and scientific papers
Pyrrolo[3,4-c]quinoline-1,3-dione derivatives and synthesis method thereof
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Paragraph 0071-0074; 0200-0206, (2016/10/10)
The present invention relates to a synthesis method of a pyrrolo[3,4-c]quinoline-1,3-dione derivative, wherein different kinds of pyrrolo[3,4-c]quinoline-1,3-dione derivatives representing various biological activities can be manufactured with a high yield through one step reaction using a low-priced nonmetallic catalyst under a mild condition.COPYRIGHT KIPO 2015
Efficient one-step synthesis of pyrrolo[3,4-c]quinoline-1,3-dione derivatives by organocatalytic cascade reactions of isatins and β-ketoamides
Xia, Likai,Lee, Yong Rok
, p. 5254 - 5263 (2013/08/23)
We describe an efficient one-step synthesis of pyrrolo[3,4-c]quinolinedione derivatives using ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and β-ketoamides. It is the first direct conversion of isatins to pyrrolo[3,4-c]quinolinedione derivatives via C-N bond cleavage and isatin ring expansion. Furthermore, this reaction provides a one-step synthetic route for the production of biologically interesting complex molecules that are generally prepared using multi-step reactions.
