144879-62-9Relevant academic research and scientific papers
The stereoselective addition of organometallic reagents to electron-deficient alkylidenecyclohexanes; alternative linkages for cholaphane synthesis
Davis, Anthony P.,Egan, Thomas J.,Orchard, Michael G.,Cunningham, Desmond,McArdle, Patrick
, p. 8725 - 8738 (2007/10/02)
Knoevenagel condensations between t-butylcyclohexanone and malononitrile, Meldrum's acid and ethyl cyanoacetate gave electron-deficient alkenes which underwent equatorial-selective attack by chemoselective aryl organometallic reagents. Further transformat
Synthesis and X-Ray Crystal Structure of a New 'Cholaphane' with Externally Directed Functionality
Davis, Anthony P.,Orchard, Michael G.,Slawin, Alexandra M. Z.,Williams, David J.
, p. 612 - 614 (2007/10/02)
The 'cholaphane' 1 was synthesized in 26percent overall yield from cholic acid and its structure determined by X-ray crystallography; the molecule adopts an open conformation and is able to surround two molecules of tetrahydrofurane.
