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CAS

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1448799-04-9

(E)-1-(6-fluoro-5-hydroxybenzofuran-3-yl)-3-(4-methoxyphenyl)prop-2-en-1-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1448799-04-9 Structure

  • Basic information

    1. Product Name: (E)-1-(6-fluoro-5-hydroxybenzofuran-3-yl)-3-(4-methoxyphenyl)prop-2-en-1-one
    2. Synonyms: (E)-1-(6-fluoro-5-hydroxybenzofuran-3-yl)-3-(4-methoxyphenyl)prop-2-en-1-one
    3. CAS NO:1448799-04-9
    4. Molecular Formula:
    5. Molecular Weight: 312.297
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1448799-04-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (E)-1-(6-fluoro-5-hydroxybenzofuran-3-yl)-3-(4-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: (E)-1-(6-fluoro-5-hydroxybenzofuran-3-yl)-3-(4-methoxyphenyl)prop-2-en-1-one(1448799-04-9)
    11. EPA Substance Registry System: (E)-1-(6-fluoro-5-hydroxybenzofuran-3-yl)-3-(4-methoxyphenyl)prop-2-en-1-one(1448799-04-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1448799-04-9(Hazardous Substances Data)

1448799-04-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1448799-04-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,8,7,9 and 9 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1448799-04:
(9*1)+(8*4)+(7*4)+(6*8)+(5*7)+(4*9)+(3*9)+(2*0)+(1*4)=219
219 % 10 = 9
So 1448799-04-9 is a valid CAS Registry Number.

1448799-04-9Upstream product

1448799-04-9Downstream Products

1448799-04-9Relevant articles and documents

3-Acyl-5-hydroxybenzofuran derivatives as potential anti-estrogen breast cancer agents: A combined experimental and theoretical investigation

Li, Xiao-Yan,He, Bi-Feng,Luo, Hua-Jun,Huang, Nian-Yu,Deng, Wei-Qiao

, p. 4617 - 4621 (2013)

We first report the application of 3-acyl-5-hydroxybenzofurans as a scaffold to develop potential drugs for breast cancer. Seven novel derivative compounds were synthesized by using a microwave-assisted synthesis method. Those compounds exhibited different antiproliferation against human breast cancer MCF-7 cells, with the best activity of IC50 = 43.08 μM for compound 1. A Quantum Mechanics Polarized Ligand Docking (QPLD) study was carried out to investigate the binding interactions between these compounds and estrogen receptor alpha (ERα). The simulation results showed that the trend of receptor-ligand binding interactions was same as that of their antiproliferative activities. A detailed analysis indicated that compound 1 possesses the highest Van der Waals and hydrogen bond interactions compared to the other six compounds and better inhibitors are achievable by enhancing the hydrogen bond interactions. Based on these results, we addressed that 3-acyl-5-hydroxybenzofuran is an attractive scaffold for designing drugs against breast cancer.

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