1448819-62-2Relevant academic research and scientific papers
NHC-Catalyzed Radical Trifluoromethylation Enabled by Togni Reagent
Zhang, Bei,Peng, Qiupeng,Guo, Donghui,Wang, Jian
, p. 443 - 447 (2020)
An unprecedented carbene-catalyzed radical trifluoromethylation of olefins with aldehydes in the presence of Togni reagent was developed, thus providing the β-trifluoromethyl-α-substituted ketones with a broad scope and moderate to high chemical yields. Notably, this process includes a single-electron-transfer process and utilizes the persistent N-heterocyclic-carbene-bound radical as a key intermediate to trigger the cascade radical cross-coupling.
Iron-catalyzed trifluoromethylation with concomitant C-C bond formation via 1,2-migration of an aryl group
Egami, Hiromichi,Shimizu, Ryo,Usui, Yoshihiko,Sodeoka, Mikiko
supporting information, p. 7346 - 7348 (2013/09/23)
Iron-catalyzed trifluoromethylation with concomitant 1,2-migration of an aryl group starting from diaryl allyl alcohol was achieved under mild conditions. This reaction system affords α-substituted-β- trifluoromethyl carbonyl compounds in high efficiency.
