1448819-65-5Relevant academic research and scientific papers
Modular synthesis of α-aryl β-perfluoroalkyl ketones: Via N-heterocyclic carbene catalysis
Li, Jin-Mei,Wang, Zhi-Hou,Wu, Chuande,Yang, Hai-Bin
, p. 3801 - 3804 (2020)
A new general de novo synthesis of pharmaceutically important α-aryl β-perfluoroalkyl ketones has been disclosed. Compared with trifluoromethylation-initiated radical 1,2-aryl migration of α,α-diaryl allylic alcohols, this protocol employs a new strategy of biomimetic carbene catalysis to assemble alkene, aldehyde and perfluoroalkyl reagents, providing access to products with excellent flexibility of the aryl unit and perfluoroalkyl group. This method also demonstrates excellent functional group compatibility, including some Grignard reagent sensitive groups.
Iron-catalyzed trifluoromethylation with concomitant C-C bond formation via 1,2-migration of an aryl group
Egami, Hiromichi,Shimizu, Ryo,Usui, Yoshihiko,Sodeoka, Mikiko
supporting information, p. 7346 - 7348 (2013/09/23)
Iron-catalyzed trifluoromethylation with concomitant 1,2-migration of an aryl group starting from diaryl allyl alcohol was achieved under mild conditions. This reaction system affords α-substituted-β- trifluoromethyl carbonyl compounds in high efficiency.
