1448887-46-4Relevant articles and documents
Diversity oriented catalyst-free and solvent-free one-pot MCR at room temperature: Rapid and regioselective convergent approach to highly functionalized dihydro-4H-thiopyrans
Koley, Suvajit,Chowdhury, Sushobhan,Chanda, Tanmoy,Ramulu, B. Janaki,Singh, Maya Shankar
, p. 8013 - 8018 (2013)
Highly convergent and regioselective approach to hitherto unreported and synthetically demanding 6-cycloamino-2-(methyl/benzyl)sulfanyl-3-(aroyl/ hetaroyl/alkanoyl)-4-aryl-5,6-dihydro-4H-thiopyrans has been developed via one-pot three-component domino coupling of β-oxodithioesters, α,β-unsaturated aldehydes, and cyclic aliphatic secondary amines at room temperature under catalyst-free and solvent-free conditions. The attractive features of this strategy include mild conditions, short reaction time, high atom-economy, excellent yields, and efficacy of forming three new bonds (C-C, C-N and C-S) and one ring in a single stroke.