1448894-89-0

Upstream product

• 1420627-35-5 (S)-2-(1-aminoethyl)-5-chloro-3-phenylquinazoline-4(3H)-one 
• 60025-09-4 4-amino-6-chloropyrimidine-5-carbonitrile 
• 2148-56-3 2-chloro-6-aminobenzoic acid 
• 50460-70-3 2-amino-6-chloro-N-phenylbenzamide 
• 1441309-05-2 tert-butyl (S)-(1-((3-chloro-2-(phenylcarbamoyl)phenyl)amino)-1-oxopropan-2-yl)carbamate 
• 20829-96-3 5-chloro-1H-benzo[d][1,3]oxazine-2,4-dione 
• 1615680-60-8 (S)-2-(1-aminoethyl)-5-chloro-3-phenylquinazolin-4(3H)-one 2,2,2-trifluoroacetic acid salt 

Relevant academic research and scientific papers

Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856

Phosphoinositide 3-kinase (PI3K) β signaling is required to sustain cancer cell growth in which the tumor suppressor phosphatase and tensin homolog (PTEN) has been deactivated. This manuscript describes the discovery, optimization, and in vivo evaluation

COMPOSITIONS AND METHODS OF TREATING A DISEASE WITH (S)-4 AMINO-6-((1-(5-CHLORO-4-OXO-3-PHENYL-3,4-DIHYDROQUINAZOLIN-2-YL)ETHYL)AMINO)PYRIMIDINE-5-CARBONITRILE

Provided are methods that relate to a novel therapeutic strategy for the treatment of asthma. In particular, the method comprises administration of Compound A, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such compound admixed with at least one pharmaceutically acceptable excipient.