20829-96-3

Basic information

• Product Name: 5-CHLORO-3,1-BENZOXAZIN-2,4-DIONE
• Synonyms: 5-CHLORO-3,1-BENZOXAZIN-2,4-DIONE;5-CHLORO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;2H-3,1-Benzoxazine-2,4(1H)-dione, 5-chloro-;5-chloro-2H-3,1-benzoxazine-2,4(1H)-dione;5-chloro-1H-3,1-benzoxazine-2,4-dione
• CAS NO: 20829-96-3
• Molecular Formula: C₈H₄ClNO₃
• Molecular Weight: 197.57526
• Mol File: 20829-96-3.mol
• Article Data: 36

Chemical Properties

• Melting Point: 272.5-272.9 °C
• Appearance: /
• Density: 1.54 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.27±0.20(Predicted)
• CAS DataBase Reference: 5-CHLORO-3,1-BENZOXAZIN-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-3,1-BENZOXAZIN-2,4-DIONE(20829-96-3)
• EPA Substance Registry System: 5-CHLORO-3,1-BENZOXAZIN-2,4-DIONE(20829-96-3)

Safety Data

• Hazardous Substances Data: 20829-96-3(Hazardous Substances Data)

Usage

General Description

5-CHLORO-3,1-BENZOXAZIN-2,4-DIONE is a chemical compound with the molecular formula C8H3ClNO3. It is a benzoxazinone derivative, which is a class of heterocyclic compounds containing a benzene ring fused to an oxazine ring with a keto group at the C-4 position. 5-CHLORO-3,1-BENZOXAZIN-2,4-DIONE is known for its potential applications in the field of pharmaceuticals and organic synthesis. It possesses a chlorine atom at the 5th position of the benzene ring and has been studied for its potential biological activities, including its role as an antibacterial and antifungal agent. Additionally, 5-CHLORO-3,1-BENZOXAZIN-2,4-DIONE has also been studied for its potential use as a starting material for the synthesis of other organic compounds and as a precursor in chemical reactions.

Upstream product

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Downstream Products

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Relevant articles and documents

Preparation method and intermediate of benzoxazine dione compound C

The invention discloses a preparation method of a benzoxazine dione compound C and an intermediate of the benzoxazine dione compound C. The method I comprises the following steps: (1) reacting a compound SM01 with N,N'-disuccinimido carbonate to obtain an

NOVEL PIPERIDINE-2,6-DIONE DERIVATIVE AND USE THEREOF

The present disclosure relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1 according to the present disclosure specifically binds with CRBN protein, and is involved in functions thereof. Therefore, the compound of the present disclosure can be favorably used in the prevention or treatment of leprosy, chronic graft versus host disease, an inflammatory disease, or cancer, which are caused by actions of CRBN protein.

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1–3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1–3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L?1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L?1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.