144890-29-9

Upstream product

• 140-10-3 (E)-3-phenylacrylic acid 
• 1903-27-1 cyclopentylidene acetic acid 
• 144890-21-1 [2-Oxo-4-(2-oxo-cyclopentyl)-4-phenyl-butyl]-phosphonic acid diethyl ester 
• 120-92-3 cyclopentanone 
• 113848-07-0 le cinnamyl-2 oxo-2 ethylphosphonate de diethyle 
• 19980-43-9 1-(trimethylsilyloxy)cyclopentene 
• 6053-71-0 2-cyclopentyl-2-hydroxyacetic acid 

Relevant academic research and scientific papers

Dienediolates of Unsaturated Carboxylic Acids in Synthesis. Synthesis of Cyclohexenones and Polycyclic Ketones by Tandem Michael-Dieckmann Decarboxylative Annulation of Unsaturated Carboxylic Acids.

Substituted 2-cyclohexenones 4 to 7 and hexahydronaphthalenones and hexahydroindenones 13 to 18 are prepared by tandem Michael-Dieckmann addition of lithium dienediolates of acyclic and alicyclic unsaturated carboxylic acids to the lithium salts of the same or other unsaturated carboxylic acids.

A New Annulation Reagent, 2-Oxo-3-alkenylphosphonates. Reactions with Carbonyl-Stabilized Carboanions or Silyl Enol Ethers Leading to Cyclohexanones

The reactions of 2-oxo-3-alkenylphosphonates with carbonyl-stabilized carbanions directly lead to 2-cyclohexen-1-ones through a sequence of Michael reaction and intramolecular Horner-Emmons olefination.On the other hand, the Lewis acid-mediated reactions with silyl enol ethers produce 1,5-diketones as Michael adducts, which then undergo cyclization on treatment with sodium hydride or triethylamine/zinc (II) bromide to afford 2-cyclohexen-1-ones or 2-phosphinyl-2-cyclohexen-1-ones, respectively.