1448960-16-4

Basic information

• Product Name: (±)-3-benzyl-(5Z)-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzylidene]thiazolidine-2,4-dione
• Synonyms: (±)-3-benzyl-(5Z)-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzylidene]thiazolidine-2,4-dione
• CAS NO: 1448960-16-4
• Molecular Weight: 529.657
• Mol File: 1448960-16-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (±)-3-benzyl-(5Z)-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzylidene]thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-3-benzyl-(5Z)-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzylidene]thiazolidine-2,4-dione(1448960-16-4)
• EPA Substance Registry System: (±)-3-benzyl-(5Z)-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzylidene]thiazolidine-2,4-dione(1448960-16-4)

Safety Data

• Hazardous Substances Data: 1448960-16-4(Hazardous Substances Data)

Upstream product

• 1375483-15-0 carbonic acid tert-butyl ester 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester 
• 100-39-0 benzyl bromide 
• 1448960-17-5 (±)-carbonic acid 2-[4-(3-benzyl-2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]-2,5,7,8-tetramethylchroman-6-yl tert-butyl ester 

Relevant articles and documents

Optimization of troglitazone derivatives as potent anti-proliferative agents: Towards more active and less toxic compounds

Δ2-Troglitazone derivatives were shown to exhibit anti-proliferative activity in a PPARγ-independent manner. We prepared various compounds in order to increase their potency and decrease their toxicity towards non-malignant primary cultured hepatocytes. Many compounds induced viabilities less than 20% at 10 μM on various cancer cell lines. Furthermore, five of them showed hepatocyte viability of 80% or more at 200 μM. In addition, compounds 17 and 18 exhibited promising maximum tolerated doses on a murine model, enabling future investigations.