1448992-18-4

Upstream product

• 1091909-58-8 4-(4-fluorophenyl)-2-hydroxy-6-methylpyrimidine-5-carboxylic acid ethyl ester 
• 459-57-4 4-fluorobenzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 1091909-58-8 ethyl 4-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 5937-24-6 ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Downstream Products

• 1448992-24-2 ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid–pyrimidine conjugates

Abstract: Designing small molecule-based new drug candidates through structure modulation of the existing drugs has drawn considerable attention in view of inevitable emergence of resistance. A new series of isoniazid–pyrimidine conjugates were synthesize

Acridone-pyrimidine hybrids- design, synthesis, cytotoxicity studies in resistant and sensitive cancer cells and molecular docking studies

Hybrid systems of acridones with substituted pyrimidines were designed with an objective of discovering next generation anticancer agents targeting multiple mechanisms in the cancer cell. Hybrid compounds were synthesized by simple and convenient methods

Pyrimidine-5-carboxylic acid ester compound and its preparation method and application

The invention discloses a pyrimidine-5-formate compound as well as a preparation method and an application thereof. The pyrimidine-5-formate compound is shown as a formula 1, wherein in the formula 1, R1 is methyl, ethyl, propyl, n-butyl, isopropyl, tert-butyl, cyclopentyl, cyclohexyl or substituted phenyl or benzyl. The synthetic route comprises the following steps: reacting urea, ethyl acetoacetate and p-fluorobenzaldehyde to obtain 4-(4-fluorophenyl)-6-methyl-2-carbonyl-1,2,3,4-tetrahydropyrimidine-5-ethyl formate; reacting to obtain 4-(4-fluorophenyl)-2-hydroxy-6-methylpyrimidine-5-ethyl formate under the action of an oxidizing agent; reacting the 4-(4-fluorophenyl)-2-hydroxy-6-methylpyrimidine-5-ethyl formate with a chlorinated reagent to obtain 2-chloro-4-(4-fluorophenyl)-6-methylpyrimidine-5-ethyl formate; and finally, reacting with substituted amine to obtain the target compound. The pyrimidine-5-formate compound can effectively prevent and control broad leaf weeds and is safe to graminaceous crops.

Primaquine-pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity

Abstract A series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver

Synthesis of 4-aminoquinoline - Pyrimidine hybrids as potent antimalarials and their mode of action studies

One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of