1449013-56-2Relevant academic research and scientific papers
SNAr-derived decomposition by-products involving pentafluorophenyl triazolium carbenes
Zhao, Xiaodan,Glover, Garrett S.,Oberg, Kevin M.,Dalton, Derek M.,Rovis, Tomislav
, p. 1229 - 1232 (2013)
Pentafluorophenyl triazolium carbenes, widely used in NHC catalysis, can decompose by several mechanisms. Under high concentration conditions, the azolium may undergo a pentafluorophenyl exchange by a proposed SNAr mechanism to give an inactive salt. In the presence of appropriate substrates, cyclization on the ortho-position of the arene can occur, also by S NAr. These adducts provide a potential pathway for catalyst decomposition and serve as a caveat to the development of new reactions and catalysts. Georg Thieme Verlag Stuttgart. New York.
