1449014-71-4Relevant academic research and scientific papers
Enantioselective Organocatalytic Intramolecular Aza-Diels–Alder Reaction
Jarrige, Lucie,Blanchard, Florent,Masson, Géraldine
, p. 10573 - 10576 (2017)
A highly efficient catalytic enantioselective intramolecular Povarov reaction was developed with primary anilines as 2-azadiene precursors. A wide variety of angularly fused azacycles were obtained without column chromatography in high to excellent yields and with excellent diastereo- and enantioselectivity (d.r.>99:1 and up to e.r. 99:1). Furthermore, the catalyst loading could be lowered to 1 mol %, and the obtained azacycles could be used as key intermediates for further transformations to generate additional molecular diversity.
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease
Simoni, Elena,Serafini, Melania M.,Bartolini, Manuela,Caporaso, Roberta,Pinto, Antonella,Necchi, Daniela,Fiori, Jessica,Andrisano, Vincenza,Minarini, Anna,Lanni, Cristina,Rosini, Michela
, p. 1309 - 1317 (2016/07/21)
The amyloidogenic pathway is a prominent feature of Alzheimer's disease (AD). However, growing evidence suggests that a linear disease model based on β-amyloid peptide (Aβ) alone is not likely to be realistic, which therefore calls for further investigati
