1449116-83-9

Basic information

• Product Name: N-(2-fluorophenyl)-N-methylmethacrylamide
• Synonyms: N-(2-fluorophenyl)-N-methylmethacrylamide
• CAS NO: 1449116-83-9
• Molecular Weight: 193.221
• Mol File: 1449116-83-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-(2-fluorophenyl)-N-methylmethacrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-fluorophenyl)-N-methylmethacrylamide(1449116-83-9)
• EPA Substance Registry System: N-(2-fluorophenyl)-N-methylmethacrylamide(1449116-83-9)

Safety Data

• Hazardous Substances Data: 1449116-83-9(Hazardous Substances Data)

Upstream product

• 1978-38-7 2-fluoro-N-methylaniline 
• 920-46-7 Methacryloyl chloride 
• 348-54-9 2-Fluoroaniline 
• 125509-82-2 N-(2-fluorophenyl)methacrylamide 
• 74-88-4 methyl iodide 

Downstream Products

• 1587688-79-6 C₁₈H₁₆F₃NO₃S 

Relevant articles and documents

Synthesis of Dichlorocyanomethyl-Functionalized Oxindoles by Cascade Reactions Initiated by Copper(I)-Catalytically Generated Dichlorocyanomethyl Radical

An efficient and convenient protocol for synthesis of dichlorocyanomethyl-functionalized oxindoles through the cascade reactions of dichlorocyanomethyl radical with N-arylacrylamides is reported. The electrophilic dichlorocyanomethyl radical, which is gen

Copper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant

An unprecedented N-demethylation of N-methyl amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.

Synthesis of oxindoles via Cu-mediated reactions between N-phenylacrylamides and ethyl 2-bromo-2-methylpropionate

A novel way of synthesizing alkylated oxindoles via Cu-mediated atom transfer radical addition reaction between N-phenylacrylamides and ethyl 2-bromo-2-methylpropionate has been described. It was found that the use of N,N,N′,N′-1,1,2,2,-tetramethylethylenediamine as ligand was important for achieving good yields. Additionally, the use of DMSO as solvent and running the reaction at 130 °C were also crucial. In some cases, the product can be further brominated when the reaction temperature was raised to 150 °C.