1449124-96-2Relevant academic research and scientific papers
Concise synthesis of (+)-allo-kainic acid via MgI2-mediated tandem aziridine ring opening-formal [3 + 2] cycloaddition
Arena, Giada,Chen, C. Chun,Leonori, Daniele,Aggarwal, Varinder K.
, p. 4250 - 4253 (2013/09/12)
3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S N2′ ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been applied to a concise asymmetric synthesis of (+)-allo-kainic acid.
