1449216-42-5

Basic information

• Product Name: 2-(4-(tert-butyl)phenyl)-N,N-diethyl-2-phenylacetamide
• Synonyms: 2-(4-(tert-butyl)phenyl)-N,N-diethyl-2-phenylacetamide
• CAS NO: 1449216-42-5
• Molecular Weight: 323.478
• Mol File: 1449216-42-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-(tert-butyl)phenyl)-N,N-diethyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(tert-butyl)phenyl)-N,N-diethyl-2-phenylacetamide(1449216-42-5)
• EPA Substance Registry System: 2-(4-(tert-butyl)phenyl)-N,N-diethyl-2-phenylacetamide(1449216-42-5)

Safety Data

• Hazardous Substances Data: 1449216-42-5(Hazardous Substances Data)

Upstream product

• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 2431-96-1 N,N-diethylphenylacetamide 
• 108-86-1 bromobenzene 
• 685-91-6 diethylacetamide 
• 108-90-7 chlorobenzene 
• 3972-56-3 4-(tert-butyl)chlorobenzene 

Relevant articles and documents

A general and practical palladium-catalyzed direct a-arylation of amides with aryl halides

An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented. The palladium catalyst is supported by Kwong's indolebased phosphine ligand and provides monoarylated amides in up to 95% yield. Excellent chemoselectivities (>10:1) in the mono- and diarylation with aryl bromides were achieved by careful selection of bases, solvents, and stoichiometry. Under the coupling conditions, the weakly acidic α-protons of amides (pK a up to 35) were reversibly depotonated by lithium tert-butoxide (LiO-t-Bu), sodium tert-butoxide (NaO-t-Bu) or sodium bis(trimethylsilyl)amide [NaN(SiMe3)2].