1449221-74-2

Basic information

• Product Name: ethyl 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylate
• Synonyms: ethyl 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylate
• CAS NO: 1449221-74-2
• Molecular Weight: 440.4
• Mol File: 1449221-74-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylate(1449221-74-2)
• EPA Substance Registry System: ethyl 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylate(1449221-74-2)

Safety Data

• Hazardous Substances Data: 1449221-74-2(Hazardous Substances Data)

Upstream product

• 2927-97-1 4-nitro-N-(3-(trifluoromethyl)phenyl)benzenesulfonamide 
• 339-40-2 4-amino-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamide 
• 1449221-73-1 1,3-diethyl 2-(((4-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)phenyl)amino)methylene)malonate 
• 98-16-8 3-trifluoromethylaniline 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 388621-83-8 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1449221-40-2 N-(4-fluorobenzyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-41-3 N-(3-fluorobenzyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-42-4 N-(4-methoxybenzyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-44-6 N-(3-methoxybenzyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-46-8 N-(furan-2-ylmethyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 898191-84-9 4-oxo-N-(pyridin-3-ylmethyl)-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 898217-34-0 N-cyclohexyl-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 

Relevant articles and documents

4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: Synthesis, biological evaluation and docking studies

In this work, we report a series of new 4-oxo-1,4-dihydro-quinoline-3- carboxamide derivatives as β-secretase (BACE-1) inhibitors. Supported by docking study, a small library of derivatives were designed, synthesized and biologically evaluated in vitro. The studies revealed that the most potent analog 14e (IC50 = 1.89 μM) with low cellular cytotoxicity and high predicted blood brain barrier permeability, could serve as a good structure for further modification.