388621-83-8

Basic information

• Product Name: 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylic acid
• Synonyms: 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylic acid
• CAS NO: 388621-83-8
• Molecular Weight: 412.346
• Mol File: 388621-83-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylic acid(388621-83-8)
• EPA Substance Registry System: 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylic acid(388621-83-8)

Safety Data

• Hazardous Substances Data: 388621-83-8(Hazardous Substances Data)

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 98-16-8 3-trifluoromethylaniline 
• 1449221-74-2 ethyl 4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxylate 
• 1449221-73-1 1,3-diethyl 2-(((4-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)phenyl)amino)methylene)malonate 
• 339-40-2 4-amino-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamide 
• 2927-97-1 4-nitro-N-(3-(trifluoromethyl)phenyl)benzenesulfonamide 

Downstream Products

• 1449221-40-2 N-(4-fluorobenzyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-41-3 N-(3-fluorobenzyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-42-4 N-(4-methoxybenzyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-44-6 N-(3-methoxybenzyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-46-8 N-(furan-2-ylmethyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 898191-84-9 4-oxo-N-(pyridin-3-ylmethyl)-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 
• 898217-34-0 N-cyclohexyl-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide 

Relevant articles and documents

4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: Synthesis, biological evaluation and docking studies

In this work, we report a series of new 4-oxo-1,4-dihydro-quinoline-3- carboxamide derivatives as β-secretase (BACE-1) inhibitors. Supported by docking study, a small library of derivatives were designed, synthesized and biologically evaluated in vitro. The studies revealed that the most potent analog 14e (IC50 = 1.89 μM) with low cellular cytotoxicity and high predicted blood brain barrier permeability, could serve as a good structure for further modification.