1449248-83-2Relevant academic research and scientific papers
Palladium-catalyzed synthesis of natural and unnatural 2-, 5-, and 7-oxygenated carbazole alkaloids from N-arylcyclohexane enaminones
Bautista, Rafael,Montoya, Pablo A.,Rebollar, Araceli,Burgueno, Eleuterio,Tamariz, Joaquin
, p. 10334 - 10351 (2013)
A palladium-catalyzed synthesis of the carbazole framework is described, including the preparation of 2-, 5-, and 7-oxygenated natural and unnatural carbazole alkaloids. A series of N-arylcyclohexane enaminones, generated by condensation of cyclohexane-1,3-dione with diverse anilines, were aromatized by a Pd(0)-catalyzed thermal treatment to afford the corresponding diarylamines. The latter were submitted to a Pd(II)-catalyzed cyclization and methylation processes to provide the desired carbazoles, including clausine V. Following an inverse strategy, a new and short total synthesis of glycoborine is also reported.
Synthesis of 2-hydroxy-7-methylcarbazole, glycozolicine, mukoline, mukolidine, sansoakamine, clausine-H, and clausine-K and structural revision of clausine-TY
Schuster, Christian,Boerger, Carsten,Julich-Gruner, Konstanze K.,Hesse, Ronny,Jaeger, Anne,Kaufmann, Gyoerley,Schmidt, Arndt W.,Knoelker, Hans-Joachim
, p. 4741 - 4752 (2014/08/05)
A Buchwald-Hartwig amination and palladium(II)-catalyzed oxidative cyclization reaction sequence provided efficient access to a series of oxygenated tricyclic carbazoles. In the present work, this approach was applied to the total syntheses of the natural
