14493-37-9Relevant academic research and scientific papers
Optimizing the reversibility of hydrazone formation for dynamic combinatorial chemistry
Nguyen, Regis,Huc, Ivan
, p. 942 - 943 (2007/10/03)
Hydrazones from hydrazines bearing electron withdrawing groups, and aromatic or aliphatic aldehydes form and hydrolyse rapidly in water at neutral pH.
SYNTHESES AND PROPERTIES OF N-AMINOPYRIMIDINES
Kohda, Kohfuku,Kobayashi, Isao,Itano, Kenji,Asano, Shoji,Kawazoe, Yutaka
, p. 3947 - 3958 (2007/10/02)
Syntheses of the positional isomers of N-aminopyrimidine bases (1- and 3-amino derivatives of uracil, thymine, and cytosine), 3-aminopyrimidine deoxyribonucleosides (3-amino derivatives of deoxyuridine, thymidine, deoxycytidine), and related compounds are reported.Physicochemical properties of these N-aminopyrimidines are described.
Novel uracil derivatives: Newly synthesized centrally acting agents
Imaizumi,Kano,Sakata
, p. 1808 - 1813 (2007/10/02)
A series of 1-amino-5-substituted uracils and their 4-thio or 2,4-dithio substituted analogues were synthesized and assayed for anti-conflict activity in rats and anesthetic activity in mice. 1-Amino-5-halogenouracils 3b-e, 1-amino-4-thiouracil (9a), and 1-amino-5-halogeno-4-thiouracils 9c, d showed both anti-conflict and anesthetic activities. The most active compound was 1-amino-5-chloro-4-thiouracil (9d) which showed anxiolytic activity at 2 mg/kg of oral administration (p.o.) on a modified Geller-Seifter conflict schedule. Its minimum effective dose (MED) was lower than that of diazepam. The 50 percent effective dose (ED50) for anesthetic activity in mice of the compound (9d) was 32.9 mg/kg, p.o.
