1449327-63-2Relevant academic research and scientific papers
Cyclopropanes in Nicholas reaction: Formation of spiroketals with a five-membered and a seven- or an eight-membered ring This paper is dedicated to Professor Paul A. Wender, one of the most creative contributors to the broad discipline of organic chemistry, on the occasion of the Tetrahedron Prize
Mukai, Chisato,Kojima, Takahiro,Kawamura, Takamasa,Inagaki, Fuyuhiko
, p. 7659 - 7669 (2013/08/23)
The consecutive treatment of 5-hydroxy-1-pentynyl 2,2-disubstituted- cyclopropyl ketones with Co2(CO)8 and BF 3·OEt2 produced the corresponding Co 2(CO)6-complexed dioxaspiro[4.6] derivatives. The one-carbon homologated substrates also afforded dioxaspiro[4.7]. It was found that this procedure can be applied to the substrates with gem-disubstituents as well as a mono-aryl substituent on the cyclopropane, but the mono-alkyl substituted cyclopropanes are insufficient.
