1449370-38-0

Basic information

• Product Name: C₂₀H₁₇NO₅S
• CAS NO: 1449370-38-0
• Molecular Weight: 383.425
• Mol File: 1449370-38-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₇NO₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₇NO₅S(1449370-38-0)
• EPA Substance Registry System: C₂₀H₁₇NO₅S(1449370-38-0)

Safety Data

• Hazardous Substances Data: 1449370-38-0(Hazardous Substances Data)

Upstream product

• 99-07-0 3-Dimethylaminophenol 
• 55804-64-3 ethyl 7-(dimethylamino)-2-oxo-2H-benzopyran-3-carboxylate 
• 41602-56-6 4-dimethylamino-2-hydroxy-benzaldehyde 

Relevant articles and documents

Development of fluorogenic probes for quick No-Wash live-cell imaging of intracellular proteins

We developed novel fluorogenic probes for no-wash live-cell imaging of proteins fused to PYP-tag, which is a small protein tag recently reported by our group. Through the design of a new PYP-tag ligand, specific intracellular protein labeling with rapid kinetics and fluorogenic response was accomplished. The probes crossed the cell membrane, and cytosolic and nuclear localizations of PYP-tagged proteins without cell washing were visualized within a 6-min reaction time. The fluorogenic response was due to the environmental effect of fluorophore upon binding to PYP-tag. Furthermore, the PYP-tag-based method was applied to the imaging of methyl-CpG-binding domain localization. This rapid protein-labeling system combined with the small protein tag and designed fluorogenic probes offers a powerful method to study the localization, movement, and function of cellular proteins.