1449389-63-2Relevant academic research and scientific papers
Copper-Catalyzed Chemo- and Diastereoselective 1,3-Dipolar Cycloaddition of Carbonyl Ylide and Aldehyde-Tethered-Cyclohexadienone to Access Polycyclic Systems
Peng, Shiyong,Zhang, Hong,Zhu, Yuqi,Zhou, Ting,He, Jieyin,Chen, Nuan,Lang, Ming,Li, Hongguang,Wang, Jian
supporting information, p. 4532 - 4537 (2021/08/09)
A copper-catalyzed tandem intermolecular ylide formation/intramolecular cycloaddition of diazo compounds and aldehyde-tethered-cyclohexadienones was reported, chemo- and diastereoselectively providing oxapolycyclic frameworks in moderate to excellent yields under mild conditions. This reaction creates two C?C bonds and one C?O bond with five stereocentres including two all-carbon quaternary centres. Moreover, the late-stage diversification of products can be realized via chemoselective substitutions. (Figure presented.).
Desymmetrization of cyclohexadienones via intramolecular stetter reaction to construct tricyclic carbocycles
Jia, Min-Qiang,You, Shu-Li
, p. 1201 - 1204 (2013/07/19)
N-Heterocyclic carbene catalyzed desymmetrization of cyclohexadienones to construct tricyclic carbocycles via an intramolecular enantioselective Stetter reaction was realized. With 10 mol% of d-camphor-derived triazolium salt E and 10 mol% of KOAc, various substituted tricyclic carbocycles bearing a quaternary carbon stereogenic center and two contiguous stereocenters were obtained in excellent yields with up to 89% ee. Georg Thieme Verlag Stuttgart New York.
