1449423-07-7Relevant academic research and scientific papers
Synthesis and antiviral activity of N-phenylbenzamide derivatives, a novel class of enterovirus 71 inhibitors
Ji, Xing-Yue,Wang, Hui-Qiang,Hao, Lan-Hu,He, Wei-Ying,Gao, Rong-Mei,Li, Yan-Ping,Li, Yu-Huan,Jiang, Jian-Dong,Li, Zhuo-Rong
, p. 3630 - 3640 (2013)
A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4- bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8-12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs.
