Molecules p. 3630 - 3640 (2013)
Update date:2022-07-29
Topics:
Ji, Xing-Yue
Wang, Hui-Qiang
Hao, Lan-Hu
He, Wei-Ying
Gao, Rong-Mei
Li, Yan-Ping
Li, Yu-Huan
Jiang, Jian-Dong
Li, Zhuo-Rong
A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4- bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8-12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs.
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Doi:10.1021/ja407223g
(2013)Doi:10.1039/c6cc05391b
(2016)Doi:10.1002/ejoc.201300331
(2013)Doi:10.1039/c3cc43875a
(2013)Doi:10.1002/anie.201303875
(2013)Doi:10.1016/S0040-4039(00)79028-9
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