1449427-01-3Relevant academic research and scientific papers
Developments in Meyers' lactamization methodology: En route to Bi(hetero)aryl structures with defined axial chirality
Postikova, Svetlana,Sabbah, Mohamad,Wightman, Daniel,Nguyen, Ich Tuan,Sanselme, Morgane,Besson, Thierry,Briere, Jean-Francois,Oudeyer, Sylvain,Levacher, Vincent
, p. 8191 - 8197 (2013)
Highly atroposelective Meyers' lactamization promoted by pivalic acid under microwave irradiation is reported which allows the construction of nonracemic substituted-dibenzo(di)azepine derivatives through a center to axial chirality transfer principle, controlling the otherwise configurationally labile biaryl axis. This approach provides a straightforward entry to enantioenriched analogues of biorelevant architectures.
