Developments in Meyers' lactamization methodology: En route to Bi(hetero)aryl structures with defined axial chirality

Article abstract of DOI:10.1021/jo401259w

Highly atroposelective Meyers' lactamization promoted by pivalic acid under microwave irradiation is reported which allows the construction of nonracemic substituted-dibenzo(di)azepine derivatives through a center to axial chirality transfer principle, controlling the otherwise configurationally labile biaryl axis. This approach provides a straightforward entry to enantioenriched analogues of biorelevant architectures.