1449475-41-5Relevant academic research and scientific papers
SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease
Credille, Cy V.,Morrison, Christine N.,Stokes, Ryjul W.,Dick, Benjamin L.,Feng, Yifan,Sun, Jiaxing,Chen, Yao,Cohen, Seth M.
, p. 9438 - 9449 (2019)
Significant efforts have been reported on the development of influenza antivirals including inhibitors of the RNA-dependent RNA polymerase PA N-terminal (PAN) endonuclease. Based on recently identified, highly active metal-binding pharmacophore
BENZIIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS
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Page/Page column 179; 180, (2013/08/15)
The invention relates to benzimidazole and imidazopyridine derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new Nav1.8 modulators of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7. X and Y are as defined in the description. Nav1.8 modulators are potentially useful in the treatment of a wide range of disorders, particularly pain.
