1449481-83-7Relevant academic research and scientific papers
NHC-catalyzed oxidative γ-addition of α,β-unsaturated aldehydes to isatins: A high-efficiency synthesis of spirocyclic oxindole-dihydropyranones
Liu, Rui,Yu, Chenxia,Xiao, Zhaoxin,Li, Tuanjie,Wang, Xiangshan,Xie, Yuanwei,Yao, Changsheng
supporting information, p. 1885 - 1891 (2014/03/21)
This manuscript discloses an efficient construction of the spirocyclic oxindole-dihydropyranone scaffold via the N-heterocyclic carbene (NHC)-catalyzed oxidative γ-functionalization of α,β-unsaturated aldehydes bearing γ-H with isatin derivatives. The ready availability of the starting materials, easy work-up, mild reaction conditions and the potential utilization value of the products make this strategy attractive.
N-heterocyclic-carbene-catalyzed reaction of α-Bromo-α,β- unsaturated aldehyde or α,β-dibromoaldehyde with isatins: An efficient synthesis of spirocyclic oxindole-dihydropyranones
Yao, Changsheng,Xiao, Zhaoxin,Liu, Rui,Li, Tuanjie,Jiao, Weihui,Yu, Chenxia
supporting information, p. 456 - 459 (2013/02/23)
Smooth as isatin! A straightforward synthesis of spirocyclic oxindole-dihydropyranones through an N-heterocyclic-carbene-catalyzed [4+2] annulation of α-bromo-α,β-unsaturated aldehydes or α,β-dibromoaldehyde bearing γ-H with isatin derivatives under mild
